Le scénariste Charlie Kaufman est rongé par le doute. Engagé pour adapter à l'écran un livre tiré de la vie de John Laroche, chasseur et trafiquant d'orchidées dans les Everglades, il est totalement bloqué. Comme Susan Orlean, la brillante journaliste new-yorkaise qui a rédigé le roman, Charlie est incapable de vivre une véritable histoire d'amour.Donald, son frère jumeau, aggrave la situation : non seulement, il réussit sans peine comme scénariste, mais il remporte également un franc succès auprès des femmes, ce qui n'est pas le cas de Charlie.Un jour, ce dernier croit avoir trouvé une solution : il va utiliser ses problèmes personnels comme base d'un scénario sur Laroche et Susan Orlean. Mais alors que l'inspiration vient et que l'histoire prend forme, Charlie va déclencher une série d'évènements qui vont bouleverser la vie de tous les protagonistes.
While his latest movie "Being John Malkovich" is in production, screenwriter Charlie Kaufman is hired by Valerie Thomas to adapt Susan Orlean's non-fiction book "The Orchid Thief" for the screen. Thomas bought the movie rights before Orlean wrote the book, when it was only an article in The New Yorker. The book details the story of rare orchid hunter John Laroche, whose passion for orchids and horticulture made Orlean discover passion and beauty for the first time in her life. Charlie wants to be faithful to the book in his adaptation, but despite Laroche himself being an interesting character in his own right, Charlie is having difficulty finding enough material in Laroche to fill a movie, while equally not having enough to say cinematically about the beauty of orchids. At the same time, Charlie is going through other issues in his life. His insecurity as a person doesn't allow him to act upon his feelings for Amelia Kavan, who is interested in him as a man. And Charlie's twin brother, pretentious Donald Kaufman, has moved into his house with a goal of also becoming a screenwriter. Despite not admiring Donald as a screenwriter, Charlie asks for his advice. Together, they feel that there is some interesting subtext in the book on which Orlean herself can only elaborate, if only Charlie has the nerve to talk to her. If she can't or won't elaborate, they may have to find out the meaning of that subtext on their own.