L'adaptation du célèbre jeu de société. Six personnes sont invitées à passer une soirée dans un manoir. Six meurtres sont commis. L'inspecteur Butler enquête pour attribuer à chaque invité le meurtre qu'il a commis.
Clue is a movie about 6 guests, a butler, and a maid, who are all involved in the murders of 6 people. The guests all meet at Hill House, where you learn that Professor Plum works in D.C., where everyone else lives. Colonel Mustard is a client of Miss Scarlet, who is the ex-employer of Yvette, the maid, who had an affair with the husband of Mrs. White, etc. When Mr. Boddy, who is blackmailing each guest, gives the guests each a weapon, he tells them they should kill Wadsworth, the butler, to avoid being exposed. With Mrs. Peacock's craziness, and Mr. Green's clumsiness, the whole group finds themselves tangled in a web of murder, lies, and hilarity.